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Detailed Info on Drug Interactions With Verelan PM

CYP 3A4 Inhibitors
Verelan PM is broken down (metabolized) by certain liver enzymes known as CYP 3A4 enzymes. Other medications (known as CYP 3A4 inhibitors) that slow the activity of these enzymes can increase the level of Verelan PM in the blood, perhaps leading to increased and possibly dangerous side effects. Check with your healthcare provider before taking Verelan PM with any of these medications. If you have already been taking such medications with Verelan PM, check with your healthcare provider before stopping them.
  
Digoxin (Digitek, Lanoxin)
Verelan PM may increase the level of digoxin in your blood (although studies have shown conflicting results). Because changes in digoxin levels can be dangerous, your healthcare provider should closely monitor the level of digoxin in your blood and adjust your dosage as necessary. Your healthcare provider should also monitor your heart rate, as Verelan PM and digoxin can both lower your heart rate.
 
Disopyramide (Norpace)
Because both disopyramide and Verelan PM decrease the heart's ability to pump blood forcefully, disopyramide should not be taken within 48 hours before, or 24 hours after, taking Verelan PM.
 
Flecainide (Tambocor)
Combining Verelan PM with flecainide may decrease the heart's ability to pump blood forcefully and may decrease the heart rate too much. Your healthcare provider should monitor you closely when combining these two medications.
 
Grapefruit Juice
Grapefruit juice can increase the level of Verelan PM in your blood, increasing your risk of side effects. Grapefruit juice should be avoided in most cases. However, if your healthcare provider decides that it is okay for you to drink grapefruit juice, you should do so consistently and in moderation.
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