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More Drug Interactions With Ziac

Clonidine
If you take clonidine and Ziac, stopping clonidine (without stopping Ziac) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. People are generally advised to stop taking Ziac several days before gradually reducing the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider.
 
Corticosteroids
Corticosteroids can increase the risk of low potassium levels (hypokalemia) when combined with Ziac, which can be dangerous. Your healthcare provider may need to monitor your potassium levels more closely if this drug interaction is a concern.
 
Diabetes Medications
The hydrochlorothiazide component of Ziac may increase the risk of high blood sugar (hyperglycemia), while the bisoprolol component may mask the symptoms of low blood sugar (hypoglycemia). Your healthcare provider may recommend that you monitor your blood sugar more closely, especially when you start or stop taking Ziac, or even when you change your dosage.
 
Digoxin
Combining Ziac with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, Ziac and digoxin should not be taken together.
 
Lithium
Taking hydrochlorothiazide (one of the active ingredients in Ziac) with lithium may increase the level of lithium in your blood, possibly increasing your chance of lithium side effects. In general, lithium should not be taken with diuretics, including hydrochlorothiazide. Your healthcare provider may need to monitor your lithium level more closely and adjust your dosage as necessary if you must take Ziac and lithium at the same time.
 
Narcotic Pain Medications
Combining Ziac with a narcotic pain medication may increase the risk of low blood pressure. This can result in lightheadedness, dizziness, or fainting, particularly if you suddenly stand up. Check with your healthcare provider before taking a narcotic pain medication with Ziac.
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Ziac Medication Information

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