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How Ziac Works and Other Indications

How Does This Medication Work?

As mentioned, Ziac contains two different active ingredients: bisoprolol and hydrochlorothiazide (also known as HCTZ).
Bisoprolol belongs to a group of drugs called beta-adrenergic blocking agents, more often known as beta blockers. These medications block beta receptors, which are located in a number of places within the body, including the heart and blood vessels. At lower doses in most people, bisoprolol helps to block a specific type of beta receptor, called beta-1 receptors (at higher doses, it also blocks beta-2 receptors). By blocking beta-1 receptors, bisoprolol decreases both heart rate and blood pressure.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water that the kidneys remove from the blood, which is then passed through the urine. As a result, hydrochlorothiazide causes a decrease in blood volume. Because of this effect, the medication can lower blood pressure and help with water retention.

Ziac Use in Children or Teens

Ziac is not approved for use in children or teens. Talk with your child's healthcare provider about the benefits and risks of giving Ziac to children.

Off-Label Uses for Ziac

On occasion, your healthcare provider may recommend Ziac for something other than high blood pressure. At this time, however, there are no universally accepted off-label Ziac uses.
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Ziac Medication Information

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