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Aceon Cough

For those taking Aceon, a cough is a common side effect, occurring in up to 12 percent of patients. The cough occurs because substances in the lungs can build up when the angiotensin-converting enzyme is blocked. An Aceon cough may appear within hours after taking the initial dose or months later. It usually stops as soon as the medicine is discontinued, but may take up to 14 days to completely go away.

Does Aceon Cause a Cough?

There are a number of possible side effects that can occur with Aceon® (perindopril erbumine). One side effect that is common in Aceon, along with all other ACE inhibitors, is a dry cough that will not go away.

Why Does This Side Effect Occur?

Aceon is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. Aceon helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes blood vessels to narrow (constrict). By blocking this enzyme, Aceon causes blood vessels to relax, which lowers blood pressure.
However, scientists also believe that the angiotensin-converting enzyme is responsible for the breakdown of other substances in the lungs. When ACE is blocked, these substances can build up in the lungs, which can ultimately lead to a chronic cough.

How Common Is a Cough With Aceon?

The likelihood of developing a cough while taking an ACE inhibitor appears to be affected by a number of factors, including the specific ACE inhibitor and a person's genetics. Some ACE inhibitors can cause a cough in up to 35 percent of people taking them.
Based on data from clinical studies, up to 12 percent of people with high blood pressure who were taking Aceon reported a cough. Up to 1.3 percent of people stopped taking their medicine because of this cough.
For people taking Aceon, a cough can first appear within hours after taking the first dose, or it may first appear months after the medicine is initially taken. Unfortunately, there is no way to know if or when a cough will occur. Once Aceon is stopped, the cough also stops (the amount of time for this can also vary).
On average, it can take up to 14 days for the cough to completely go away. In some studies, however, it has been reported to take months.
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