Hypertension Home > Moduretic

Moduretic is commonly prescribed for people who have high blood pressure or water retention associated with congestive heart failure. The drug causes a decrease in blood volume, which can lower blood pressure and help relieve fluid retention. It comes in tablet form, and is usually taken once a day. Common side effects include weakness, nausea, and dizziness.

What Is Moduretic?

Moduretic® (amiloride-HCTZ) is a prescription medicine that is used as a diuretic for high blood pressure and fluid retention. It is a combination of two diuretic medications: amiloride and hydrochlorothiazide (HCTZ).

Who Makes This Medication?

Brand-name Moduretic was originally made by Merck, but is no longer being made. Generic versions are still available, however, and are made by a few different manufacturers.

What Is Moduretic Used For?

Specific uses of Moduretic include:
(Click Moduretic Uses for more information, including possible off-label uses.)

How Does It Work?

Moduretic is a diuretic, which is commonly referred to as a "water pill." It contains two diuretics that work together to keep electrolyte levels in balance. Hydrochlorothiazide, while effective, often causes low potassium levels in the blood. On the other hand, amiloride is a "potassium-sparing" diuretic, which means that it can actually increase potassium levels in the blood. When taken together, these medications balance each other out.
Moduretic works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. By increasing the amount of water removed from the blood, the medication causes a decrease in blood volume. Because of this effect, it can lower blood pressure and can also help with water retention.
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Last reviewed by: Kristi Monson, PharmD;
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