Hypertension Home > Zaroxolyn

Zaroxolyn is commonly prescribed to treat high blood pressure and fluid retention. By increasing the amount of water and salt removed from the blood and causing a decrease in blood volume, the medication can help with water retention and reduce blood pressure. Zaroxolyn comes in tablet form and is typically taken once a day. Potential side effects include headaches, dry mouth, and depression.

What Is Zaroxolyn?

Zaroxolyn® (metolazone) is a prescription medicine that is used to treat high blood pressure (hypertension) and fluid retention (edema). It is part of a class of medicines known as diuretics.

Who Makes Zaroxolyn?

Zaroxolyn is made by UCB Pharma. Generic Zaroxolyn is made by various manufacturers.

What Is It Used For?

Specific uses of Zaroxolyn include:
(Click Zaroxolyn Uses for more information, including possible off-label uses.)

How Does It Work?

Zaroxolyn is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. By increasing the amount of water removed from the blood, Zaroxolyn causes a decrease in blood volume. Because of this effect, the drug can lower blood pressure and can also help with water retention.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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