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Side Effects of Methylsulfonylmethane

Fatigue, bloating, nausea, and trouble concentrating are some of the potential side effects of methylsulfonylmethane. Unpredictable side effects are also possible due to contaminants in the dietary supplement, since supplements are not as tightly regulated as prescription or non-prescription drugs. Seek medical attention immediately if you develop any bothersome methylsulfonylmethane side effects.

Does Methylsulfonylmethane Cause Side Effects?

Methylsulfonylmethane (MSM) is a naturally occurring compound found in many foods. It is also a popular dietary supplement. As with most dietary supplements, there is a lack of clear, quality information regarding the possible methylsulfonylmethane side effects, since supplements are typically not studied thoroughly.
(This article covers many, but not all, of the possible side effects with methylsulfonylmethane. Your healthcare provider can discuss a more complete list of methylsulfonylmethane side effects with you.)

Possible Side Effects of Methylsulfonylmethane

A few clinical studies have reported side effects with methylsulfonylmethane, although these side effects were just as common in people taking a placebo (a "sugar pill"). These possible side effects included:


    • A rash or hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


Be sure to seek immediate medical attention if you think you may be having an allergic reaction to methylsulfonylmethane.
Unpredictable methylsulfonylmethane side effects are also possible due to contaminants in methylsulfonylmethane products. Because herbs and supplements are not as tightly regulated as prescription or non-prescription drugs, they are sometimes contaminated with other herbs, medications, or even heavy metals. In order to avoid such problems, it is important to choose a high-quality supplement from a trustworthy manufacturer.
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Methylsulfonylmethane Supplements

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